---
type: CKG Bundle
title: GLP-1 Muscle Loss
tags: [Healthcare & Life Sci]
timestamp: 2026-06-18T00:00:00Z
ckg:
  id: glp1-muscle-loss
  nodes: 38
  license: CC BY 4.0
---

# GLP-1 Muscle Loss — Compressed Knowledge Graph

```csv
ConceptID,ConceptLabel,TaxonomyID
1,GLP-1 Receptor Agonists,DRUG
2,Semaglutide,DRUG
3,Tirzepatide,DRUG
4,STEP 1 Trial,DRUG
5,SURMOUNT Trial,DRUG
6,Total Weight Loss,MECH
7,Lean Mass Loss,MECH
8,39-40% Lean Mass Figure,MECH
9,Starvation Cascade,MECH
10,Caloric Deficit,MECH
11,Muscle Protein Catabolism,MECH
12,BMR Decline,MECH
13,Mitochondrial Dysfunction,MECH
14,Sarcopenic Obesity,RISK
15,Metabolic Penalty,RISK
16,Insulin Resistance Worsening,RISK
17,70% Discontinuation Crisis,RISK
18,Weight Regain Cascade,RISK
19,Net Metabolic Harm Risk,RISK
20,Protein Protocol 1.2-1.6g/kg/day,INTER
21,Resistance Training,INTER
22,Combined Protocol,INTER
23,Lean Mass Preservation,INTER
24,Myostatin Pathway,PIPELINE
25,Trevogrumab,PIPELINE
26,COURAGE Trial,PIPELINE
27,50% Lean Loss Prevention,PIPELINE
28,Apitegromab,PIPELINE
29,EMBRAZE Trial,PIPELINE
30,Myostatin Inhibitor Class,PIPELINE
31,Obesity Drug Plus Muscle Preserving,PIPELINE
32,Irony Node A: GLP-1 Causes Muscle Loss,CONTRA
33,Irony Node B: Muscle Loss Worsens Metabolic Heal,CONTRA
34,Irony Node C: Drug Treats Obesity Creates Sarcop,CONTRA
35,Protein Synthesis,INTER
36,mTOR Activation,MECH
37,Clinical Endpoint Lean Mass,PIPELINE
38,Standard of Care Gap,RISK
```

## Edges (prerequisite -> concept)
1 -> 2
1 -> 3
2 -> 4
3 -> 5
4 -> 6
5 -> 6
6 -> 7
7 -> 8
4 -> 8
7 -> 9
9 -> 10
9 -> 11
10 -> 11
11 -> 12
11 -> 13
12 -> 13
7 -> 14
12 -> 14
12 -> 15
13 -> 15
15 -> 16
14 -> 16
1 -> 17
17 -> 18
18 -> 19
16 -> 19
14 -> 19
11 -> 20
11 -> 21
12 -> 21
20 -> 22
21 -> 22
22 -> 23
11 -> 24
24 -> 25
25 -> 26
26 -> 27
24 -> 28
28 -> 29
25 -> 30
28 -> 30
30 -> 31
22 -> 31
2 -> 32
7 -> 32
7 -> 33
16 -> 33
1 -> 34
14 -> 34
20 -> 35
21 -> 35
21 -> 36
35 -> 36
27 -> 37
29 -> 37
19 -> 38
37 -> 38

*Free CKG · Graphify.md · `pip install ckg-mcp` for all · own the knowledge layer, rent the model*